Investigating the Cause and Consequences of Iron Deposition in Parkinson's Disease

Abstract

It is known that iron elevation occurs in the brain in Parkinson’s disease. This might cause cell death by ‘rusting’. It is not known (1) how iron accumulates in the disease, (2) whether iron accumulation contributes to the worsening of the disease and (3) if lowering iron with a drug would improve symptoms. We plan to address these questions using a clinical cohort of patients, and laboratory animal models.

Related publications (1)

Transferrin protects against parkinsonian neurotoxicity and is deficient in parkinson’s substantia nigra

S Ayton, P Lei, C McLean, AI Bush, DI Finkelstein

2016-01-01

Iron deposition in Parkinson’s disease (PD) is a potential disease-modifying target. We previously showed that supplementation of ..